Fire ant bites on toes11/19/2023 Serology for viral infections, rheumatic and collagen vascular diseases were all negative. Laboratory tests including cell blood count, glucose, electrolytes, renal and liver function tests were all within the normal ranges. On the inner part of the right thigh a painful pale papule was noted surrounded by erythema (Fig. On the back and palmar sides of the hands and feet there were erythematous and oedematous plaques (Fig.1A and B). On physical examination the blood pressure was 120/80 mmHg, pulse rate 85 bpm, temperature 37.6 ☌ and respiratory rate 12. She had no history of drug or food allergy. Her past medical history was unremarkable and she was taking no medication. The patient recalled that 3 days before admission she was bitten on the inner thigh by a brown spider. Our case is the first report in the medical literature that documents HFS as a result of spider bite.Ī 45-year-old otherwise healthy woman was admitted to our department due to appearance of red, mildly tender swellings on both hands and feet. Only one report demonstrates the occurrence of HFS in association with multiple fire ant stings (4). HFS was initially reported in association with acute crisis in sickle cell anaemia and thalassaemia and, more recently, as a common toxicity of high-dose chemotherapy administration (2, 3). Some authors use the term acral erythema or erythrodysaesthesia because of the painful erythema on the palms and soles (1). Hand–foot syndrome (HFS) is a rare erythematous skin lesion of the palmoplantar areas of hands and feet.
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